{"id":232,"date":"2025-07-22T15:28:55","date_gmt":"2025-07-22T15:28:55","guid":{"rendered":"https:\/\/sycomia.com\/?page_id=232"},"modified":"2025-09-28T21:39:40","modified_gmt":"2025-09-28T21:39:40","slug":"epigenetics","status":"publish","type":"page","link":"https:\/\/sycomia.com\/fr\/epigenetics\/","title":{"rendered":"Epig\u00e9n\u00e9tique"},"content":{"rendered":"
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Epig\u00e9n\u00e9tique<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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M\u00e9thylation de l'ADN<\/h3>\t\t\t\t<\/div>\n\t\t
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Cartographie et identification des sites de m\u00e9thylation <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons des analyses compl\u00e8tes de la m\u00e9thylation de l\u2019ADN \u00e0 l\u2019aide des m\u00e9thodes WGBS (Whole Genome Bisulfite Sequencing), RRBS (Reduced Representation Bisulfite Sequencing) et enzymatiques. Nos workflows incluent un alignement de haute qualit\u00e9 des lectures, la d\u00e9tection pr\u00e9cise des sites m\u00e9thyl\u00e9s, ainsi que des contr\u00f4les qualit\u00e9 rigoureux, garantissant des profils \u00e9pig\u00e9n\u00e9tiques fiables, reproductibles et repr\u00e9sentatifs de l\u2019ensemble du g\u00e9nome.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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M\u00e9thylation diff\u00e9rentielle <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe r\u00e9alise des analyses robustes de m\u00e9thylation diff\u00e9rentielle afin d\u2019identifier les r\u00e9gions g\u00e9nomiques pr\u00e9sentant des variations significatives de m\u00e9thylation entre diff\u00e9rentes conditions. Nos workflows sont con\u00e7us pour faciliter la d\u00e9couverte de biomarqueurs \u00e9pig\u00e9n\u00e9tiques et d\u2019\u00e9l\u00e9ments r\u00e9gulateurs associ\u00e9s aux maladies, au d\u00e9veloppement ou aux r\u00e9ponses environnementales.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Horloge biologique <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nos bio-informaticiens estiment avec pr\u00e9cision l\u2019\u00e2ge biologique \u00e0 l\u2019aide d\u2019horloges \u00e9pig\u00e9n\u00e9tiques fond\u00e9es sur la m\u00e9thylation de l\u2019ADN. En comparant l\u2019\u00e2ge \u00e9pig\u00e9n\u00e9tique \u00e0 l\u2019\u00e2ge chronologique, nous \u00e9valuons l\u2019acc\u00e9l\u00e9ration du vieillissement et ses liens potentiels avec la sant\u00e9, les pathologies et les expositions environnementales. Nos workflows garantissent des pr\u00e9dictions fiables, quel que soit le type de tissu ou le design exp\u00e9rimental.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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D\u00e9tection directe de la m\u00e9thylation \u00e0 partir des lectures Nanopore <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe est capable de d\u00e9tecter directement la m\u00e9thylation de l\u2019ADN \u00e0 partir des lectures de s\u00e9quen\u00e7age Oxford Nanopore, sans recours \u00e0 une conversion chimique. Nos pipelines exploitent les donn\u00e9es brutes au niveau du signal, pour identifier avec pr\u00e9cision les motifs de m\u00e9thylation \u00e0 l\u2019\u00e9chelle du g\u00e9nome. Cela permet une analyse \u00e9pig\u00e9n\u00e9tique en temps r\u00e9el, adapt\u00e9e aux r\u00e9gions complexes et aux variants structuraux.
<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Accessibilit\u00e9 de la Chromatine et Interactions avec des Facteurs de Transcription<\/h3>\t\t\t\t<\/div>\n\t\t
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R\u00e9gulation de l'expression des g\u00e9nes : ATAC-seq, ChIP-seq, CUT&TAG <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Sycomia offre un accompagnement pour l\u2019analyse de la chromatine \u00e0 l\u2019aide des technologies ATAC-seq, ChIP-seq et CUT&Tag. Nos workflows garantissent un pr\u00e9traitement de haute performance, incluant le contr\u00f4le qualit\u00e9, le retrait des adaptateurs et un alignement pr\u00e9cis sur les g\u00e9nomes de r\u00e9f\u00e9rence, constituant ainsi une base solide pour l\u2019exploration fiable de l\u2019accessibilit\u00e9 de la chromatine et des interactions ADN-prot\u00e9ines.<\/span>
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D\u00e9tection de pics <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nos experts r\u00e9alisent avec pr\u00e9cision la d\u00e9tection des pics, \u00e0 partir des donn\u00e9es de issues de la chromatine (ATAC-seq, ChIP-seq, CUT&Tag), afin d\u2019identifier les r\u00e9gions pr\u00e9sentant un enrichissement significatif. Nos workflows optimis\u00e9s permettent une identification affin\u00e9e des \u00e9l\u00e9ments r\u00e9gulateurs, des sites de liaison des facteurs de transcription et des pics de modifications des histones, facilitant ainsi les analyses fonctionnelles en aval.<\/span>
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Analyse des motifs <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons une analyse compl\u00e8te des motifs afin de d\u00e9tecter et caract\u00e9riser les s\u00e9quences d\u2019ADN au sein de r\u00e9gions r\u00e9gulatrices. En mettant en lumi\u00e8re les sites de liaison potentiels des facteurs de transcription, notre analyse contribue \u00e0 \u00e9lucider les r\u00e9seaux r\u00e9gulateurs qui contr\u00f4lent l\u2019expression g\u00e9nique et les fonctions cellulaires.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Analyse des interactions entre l'ARN et l'ADN : ChiRP-seq, RAP-seq <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous analysons les donn\u00e9es d\u2019interactions ARN-ADN issues d\u2019exp\u00e9riences ChIRP-seq et RAP-seq afin d\u2019identifier et de cartographier avec pr\u00e9cision les r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 des ARN sp\u00e9cifiques. Cette cartographie d\u00e9taill\u00e9e offre des perspectives pr\u00e9cieuses sur l\u2019influence des mol\u00e9cules d\u2019ARN, l\u2019organisation de la chromatine, la r\u00e9gulation g\u00e9nique et les m\u00e9canismes \u00e9pig\u00e9n\u00e9tiques. En int\u00e9grant ces donn\u00e9es avec d\u2019autres couches Omiques, nous contribuons \u00e0 r\u00e9v\u00e9ler les r\u00e9seaux r\u00e9gulateurs complexes et les r\u00f4les fonctionnels des ARN non codants dans divers processus biologiques et pathologies.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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G\u00e9nomique 3D<\/h3>\t\t\t\t<\/div>\n\t\t
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Hi-C \/ Hi-C Capture <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe propose l\u2019analyse des donn\u00e9es Hi-C et Capture Hi-C afin d\u2019explorer l\u2019organisation tridimensionnelle du g\u00e9nome. En cartographiant les interactions chromatiniennes \u00e0 diff\u00e9rentes r\u00e9solutions, ces techniques r\u00e9v\u00e8lent l\u2019architecture spatiale du g\u00e9nome ainsi que les contacts r\u00e9gulateurs essentiels \u00e0 l\u2019expression des g\u00e9nes et aux fonctions cellulaires.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Analyse des boucles de chromatine et des TADs <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous r\u00e9alisons l\u2019analyse des boucles de la chromatine et des Domaines Topologiques Associ\u00e9s (TADs) \u00e0 partir des donn\u00e9es du g\u00e9nome 3D. L\u2019identification de ces structures permet de mieux comprendre les principes d\u2019organisation du g\u00e9nome ainsi que leur r\u00f4le dans la r\u00e9gulation de l\u2019expression g\u00e9nique et la stabilit\u00e9 g\u00e9nomique.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Visualisation <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons une visualisation d\u00e9taill\u00e9e des donn\u00e9es Hi-C, mettant en \u00e9vidence les interactions chromatiniennes, les boucles et la structure tridimensionnelle du g\u00e9nome de mani\u00e8re intuitive et accessible. Cette visualisation facilite la compr\u00e9hension de l\u2019organisation spatiale du g\u00e9nome ainsi que de ses implications fonctionnelles.<\/span><\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Single-cell Epig\u00e9nomique<\/h3>\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"cell\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
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Analyse des donn\u00e9es \u00e9pig\u00e9nomiques de cellules uniques : scATAC-seq, scMethyl-seq <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe vous accompagne dans l\u2019analyse des donn\u00e9es \u00e9pig\u00e9nomiques de cellules uniques, incluant scATAC-seq et scMethyl-seq. Ces techniques permettent de d\u00e9tecter le profil de l\u2019accessibilit\u00e9 chromatinienne et de la m\u00e9thylation de l\u2019ADN \u00e0 l\u2019\u00e9chelle de la cellule unique, r\u00e9v\u00e9lant l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 cellulaire et la r\u00e9gulation \u00e9pig\u00e9n\u00e9tique au sein de tissus complexes.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Inf\u00e9rence de la trajectoire \u00e9pig\u00e9n\u00e9tique <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous utilisons des approches informatiques pour reconstruire les trajectoires \u00e9pig\u00e9n\u00e9tiques \u00e0 partir de donn\u00e9es single cell. Cela permet de suivre les changements dynamiques de l\u2019accessibilit\u00e9 chromatinienne ou de la m\u00e9thylation de l\u2019ADN, d\u00e9voilant les voies de diff\u00e9renciation cellulaire et les programmes r\u00e9gulateurs \u00e0 l\u2019\u00e9chelle de la cellule unique.<\/span>
<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Analyse conjointe avec un single-cell RNA-seq <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous int\u00e9grons les donn\u00e9es \u00e9pig\u00e9nomiques de cellules uniques avec les donn\u00e9es single-cell RNA-seq afin d\u2019offrir une vue globale des \u00e9tats cellulaires et des m\u00e9canismes r\u00e9gulateurs. Cette analyse conjointe relie les profils d\u2019expression g\u00e9nique \u00e0 l\u2019accessibilit\u00e9 chromatinienne ou \u00e0 la m\u00e9thylation, permettant une compr\u00e9hension approfondie de l\u2019identit\u00e9 et des fonctions cellulaires.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Advanced Epigenetics Solutions DNA Methylation Mapping & Methylation calling We offer comprehensive DNA methylation analysis using Whole Genome Bisulfite Sequencing […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-232","page","type-page","status-publish","hentry"],"yoast_head":"\nEpigenetics - 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