{"id":226,"date":"2025-07-22T15:28:16","date_gmt":"2025-07-22T15:28:16","guid":{"rendered":"https:\/\/sycomia.com\/?page_id=226"},"modified":"2025-09-28T21:51:32","modified_gmt":"2025-09-28T21:51:32","slug":"genomics","status":"publish","type":"page","link":"https:\/\/sycomia.com\/fr\/genomics\/","title":{"rendered":"G\u00e9nomique"},"content":{"rendered":"
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Genomique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Sycomia propose des services bio-informatiques sp\u00e9cialis\u00e9s pour les projets de g\u00e9nomique bas\u00e9s sur l\u2019ADN. Nous r\u00e9alisons les analyses de d\u00e9tection de variants, d\u2019assemblage de g\u00e9nomes, d\u2019annotation et de g\u00e9nomique comparative, en offrant des analyses de bout en bout, adapt\u00e9es \u00e0 vos questions biologiques.\nNotre \u00e9quipe garantit des r\u00e9sultats pr\u00e9cis, reproductibles et pr\u00eats pour la publication.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Analyse de Variants<\/h3>\t\t\t\t<\/div>\n\t\t
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D\u00e9couverte de Variants (SNPs, indels, CNVs) <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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\u00c0 partir de donn\u00e9es de s\u00e9quen\u00e7age du g\u00e9nome entier (WGS) ou de l\u2019exome entier (WES), nous identifions les variants, des substitutions ponctuelles aux variations plus complexes, \u00e0 l\u2019aide de nos pipelines.\nNous fournissons des jeux de donn\u00e9es de variants annot\u00e9s et filtr\u00e9s, pr\u00eats pour les \u00e9tapes d\u2019interpr\u00e9tation, qu\u2019il s\u2019agisse de projets de recherche, de diagnostics ou d\u2019\u00e9tudes de populations.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Annotation et priorisation des variants <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons une annotation et une priorisation compl\u00e8tes des variants afin d\u2019identifier les mutations biologiquement ou cliniquement pertinentes.\nGr\u00e2ce \u00e0 l\u2019utilisation de bases de donn\u00e9es s\u00e9lectionn\u00e9es avec soin et d\u2019outils pr\u00e9dictifs, nous classons les variants selon leur impact, leur fr\u00e9quence et leur potentiel de pathog\u00e9nicit\u00e9, facilitant ainsi vos d\u00e9couvertes et orientant les \u00e9tapes d\u2019interpr\u00e9tation ou de validation.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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D\u00e9tection des variants effecteurs <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe r\u00e9alise la d\u00e9tection de variants effecteurs par l\u2019analyse statistique de grandes cohortes g\u00e9nomiques.\nEn combinant des approches de type GWAS et de fine-mapping, nous identifions les variants significativement associ\u00e9s \u00e0 des ph\u00e9notypes ou \u00e0 des pathologies, et priorisons ceux pr\u00e9sentant un impact fonctionnel probable.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Analyse des signatures de mutations <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nos experts peuvent extraire et interpr\u00e9ter des signatures de mutations bas\u00e9es sur le contexte des triplets nucl\u00e9otidiques (par exemple, C>T <\/i> au sein d\u2019un motif ACG) \u00e0 partir de donn\u00e9es de mutations somatiques.\nCes signatures permettent de r\u00e9v\u00e9ler les processus mutag\u00e8nes sous-jacents.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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G\u00e9nomique des populations <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Sycomia propose des services en g\u00e9nomique des populations pour analyser la variation g\u00e9n\u00e9tique au sein et entre diff\u00e9rentes populations.\nNous fournissons des r\u00e9sultats sur la structure des populations, leur diversit\u00e9 g\u00e9n\u00e9tique et les dynamiques \u00e9volutives associ\u00e9es.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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ctDNA et Biopsie Liquide\n<\/h3>\t\t\t\t<\/div>\n\t\t
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S\u00e9quen\u00e7age \u00e0 tr\u00e8s forte couverture avec correction d\u2019erreurs via UMI <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons une analyse de l\u2019ADN tumoral circulant (ctDNA) gr\u00e2ce \u00e0 un s\u00e9quen\u00e7age \u00e0 tr\u00e8s forte couverture, associ\u00e9 \u00e0 la technologie des Identifiants Mol\u00e9culaires Uniques (UMI).\n Cette approche permet une d\u00e9tection extr\u00eamement sensible et pr\u00e9cise des mutations rares et des variants \u00e0 faible fr\u00e9quence dans les \u00e9chantillons sanguins, en \u00e9liminant les erreurs de s\u00e9quen\u00e7age.\n Notre m\u00e9thode de pointe facilite un suivi pr\u00e9cis de la dynamique tumorale et de la r\u00e9ponse au traitement.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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D\u00e9tection des variants \u00e0 basse fr\u00e9quence <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous minimisons les erreurs et atteignons une d\u00e9tection pr\u00e9cise des variants jusqu\u2019\u00e0 une fr\u00e9quence d\u2019environ 1 %.\nCela permet d\u2019obtenir des analyses d\u00e9taill\u00e9es de la g\u00e9n\u00e9tique tumorale \u00e0 partir d\u2019un simple pr\u00e9l\u00e8vement sanguin, soutenant ainsi la prise en charge personnalis\u00e9e du cancer et le suivi en temps r\u00e9el de la maladie.<\/span>

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Analyse de la charge tumorale <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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L\u2019analyse de la charge tumorale \u00e9value la quantit\u00e9 de cellules canc\u00e9reuses pr\u00e9sentes dans l\u2019organisme en d\u00e9tectant et quantifiant l\u2019ADN tumoral circulant dans le sang.\nCette mesure permet de suivre l\u2019\u00e9volution de la masse tumorale pendant ou apr\u00e8s un traitement, fournissant ainsi des informations essentielles sur l\u2019\u00e9tat et la progression de la maladie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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S\u00e9quen\u00e7age et Assemblage\n<\/h3>\t\t\t\t<\/div>\n\t\t
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Assemblage du g\u00e9nome complet (lectures courtes\/longues\/hybrides) <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe propose de r\u00e9aliser l'assemblage de g\u00e9nomes complets en utilisant des lectures de s\u00e9quen\u00e7age courtes, longues, ou hybrides.\nEn combinant la haute pr\u00e9cision des lectures courtes avec la capacit\u00e9 des lectures longues \u00e0 couvrir des r\u00e9gions complexes, notre approche d\u2019assemblage hybride offre des reconstructions g\u00e9nomiques pr\u00e9cises et compl\u00e8tes.

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Construction et comparaison de pan-g\u00e9nomes <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons une analyse avanc\u00e9e de pan-g\u00e9nome en assemblant et comparant l\u2019ensemble des g\u00e8nes de plusieurs g\u00e9nomes au sein d\u2019une m\u00eame esp\u00e8ce.\nCette approche permet d\u2019identifier les \u00e9l\u00e9ments g\u00e9n\u00e9tiques conserv\u00e9s (core-g\u00e9nome) et variables, r\u00e9v\u00e9lant la diversit\u00e9, les sch\u00e9mas \u00e9volutifs et les caract\u00e9ristiques uniques \u00e0 une esp\u00e8ce. <\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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D\u00e9termination de phase des haplotypes\u00a0 <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe propose des services de phasage d\u2019haplotypes permettant de d\u00e9terminer quels variants g\u00e9n\u00e9tiques sont h\u00e9rit\u00e9s ensemble sur un m\u00eame chromosome.\nEn reconstituant l\u2019agencement des variants, notre analyse offre une meilleure compr\u00e9hension de la structure g\u00e9n\u00e9tique, des associations avec les maladies et des modes de transmission, am\u00e9liorant ainsi la pr\u00e9cision des \u00e9tudes g\u00e9nomiques.<\/span><\/p>

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Assemblage de novo<\/i> pour les organismes non mod\u00e8les <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Gr\u00e2ce \u00e0 des technologies de s\u00e9quen\u00e7age de pointe et des pipelines d\u2019assemblage sur mesure, nous reconstruisons int\u00e9gralement des g\u00e9nomes, permettant la d\u00e9couverte de nouveaux g\u00e8nes, de variations g\u00e9n\u00e9tiques, ainsi que des informations \u00e9volutives pour des esp\u00e8ces peu \u00e9tudi\u00e9es.

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Annotation du g\u00e9nome (structurelle et fonctionnelle) <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons des services complets d\u2019annotation g\u00e9nomique, identifiant les positions et la structure des g\u00e8nes et pr\u00e9disant leurs r\u00f4les biologiques.\nNotre approche int\u00e9gr\u00e9e combine outils informatiques et bases de donn\u00e9es pour fournir des cartes pr\u00e9cises des g\u00e8nes, des \u00e9l\u00e9ments r\u00e9gulateurs et des voies biologiques, facilitant ainsi une compr\u00e9hension approfondie du fonctionnement du g\u00e9nome.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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G\u00e9nomique Comparative\n<\/h3>\t\t\t\t<\/div>\n\t\t
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D\u00e9tection d'orthologues\/paralogues <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous proposons une identification pr\u00e9cise des g\u00e8nes orthologues ou paralogues.\nCette analyse permet de mieux comprendre l\u2019\u00e9volution des g\u00e8nes, la conservation fonctionnelle et les adaptations sp\u00e9cifiques \u00e0 certaines esp\u00e8ces, contribuant ainsi aux \u00e9tudes de g\u00e9nomique comparative et d\u2019\u00e9volution.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Analyse de la synt\u00e9nie et des r\u00e9arrangements g\u00e9nomiques <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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L'\u00e9quipe de Sycomia propose une analyse d\u00e9taill\u00e9e de la synt\u00e9nie, c\u2019est-\u00e0-dire de l\u2019ordre conserv\u00e9 des g\u00e8nes entre diff\u00e9rents g\u00e9nomes, et d\u00e9tecte les r\u00e9arrangements g\u00e9nomiques tels que les inversions, translocations et duplications.\nCette approche permet de r\u00e9v\u00e9ler les relations \u00e9volutives, les variations structurelles et leurs impacts fonctionnels entre esp\u00e8ces ou au sein de populations.<\/span>

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Phylog\u00e9nomique <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous int\u00e9grons des donn\u00e9es g\u00e9nomiques \u00e0 l\u2019\u00e9chelle du g\u00e9nome entier pour reconstituer les relations \u00e9volutives entre esp\u00e8ces ou populations.\nNos analyses phylog\u00e9nomiques combinent plusieurs g\u00e8nes ou g\u00e9nomes entiers afin de construire des arbres phylog\u00e9n\u00e9tiques pr\u00e9cis, mettant en lumi\u00e8re l\u2019histoire \u00e9volutive, la sp\u00e9ciation et la diversit\u00e9 g\u00e9n\u00e9tique.<\/span>

<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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M\u00e9tag\u00e9nomique<\/h3>\t\t\t\t<\/div>\n\t\t
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Profilage taxonomique <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Nous r\u00e9alisons des profils taxonomiques afin d\u2019identifier et de quantifier les esp\u00e8ces microbiennes pr\u00e9sentes dans des \u00e9chantillons m\u00e9tag\u00e9nomiques complexes.\nGr\u00e2ce au s\u00e9quen\u00e7age haut d\u00e9bit et \u00e0 des pipelines bio-informatiques robustes, nous r\u00e9v\u00e9lons la composition et la diversit\u00e9 des communaut\u00e9s microbiennes, contribuant ainsi \u00e0 la recherche en sant\u00e9, en \u00e9cologie et en surveillance environnementale.<\/span>

<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Profilage fonctionnel <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Notre \u00e9quipe d'experts propose des services d\u2019analyses fonctionnelles visant \u00e0 r\u00e9v\u00e9ler le potentiel m\u00e9tabolique et les r\u00f4les biologiques des communaut\u00e9s microbiennes.\nEn analysant les donn\u00e9es m\u00e9tag\u00e9nomiques, nous identifions les g\u00e8nes, les voies m\u00e9taboliques et les modules fonctionnels, fournissant ainsi des cl\u00e9s pour comprendre le fonctionnement des communaut\u00e9s, les processus \u00e9cosyst\u00e9miques et les interactions h\u00f4te-microbiote.<\/span><\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"bacteria\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Advanced Genomics Solutions Sycomia provides specialized bioinformatics services for DNA-based genomics projects. We support variant detection, genome assembly, annotation, and […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-226","page","type-page","status-publish","hentry"],"yoast_head":"\nGenomics solutions - 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